Stanislav I. Svetlov, M.D., Ph.D.
Title: Senior Principal Scientist

Education: All-Union Medical Institute, Moscow, Russia, M.D., Medical Biochemistry, 1983 Institute of Pediatrics, Moscow, Russia, Ph.D., Molecular Pathology, 1991 University of Texas, San Antonio, Postdoctoral, Biochemistry, 1993-1997

Selected peer-reviewed publications (in chronological order):

1. Svetlov SI, Serebruany VL: Platelet-activating factor: biochemical and pathophysiological aspects J. Pathophysiol. Exp. Therapeutics N1:70-5, 1989.
2. Serebruany VL, Ignatova MS, Degtyareva EM, Svetlov SI: Thrombophilia in children with nephrotic syndrome. Pediatrics N1:49-53, 1989.
3. Svetlov SI, Burova VY, Kleumenovqa NV, Brydun AV, Serebruany VL, Matyushin AI, Veltischev Yu. Lung and kidney damage induced by the synthetic acetylglyceryl ether phosphorylcholine in rabbits is partially prevented by verapamyl. Bull Exp Biol Med N9:276-9, 1989.
4. Tananova GV, Kushnareva MV, Svetlov SI: Effect of different phospholipids on adhesive properties of bacteria. J Microbiol Epidemiol Immunobiol N5-6:4-7, 1992.
5. Svetlov SI, Nigam S: Evidence for the presence of high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. Biochem Biophys Res Commun 190:162-6, 1993.
6. Svetlov SI, Nigam S: Calphostin C a specific protein kinase C inhibitor, activated human neutrophils: effect on phospholipase A2 and aggregation. Biochim Biophys Acta 1177:75-8, 1993.
7. Svetlov SI, Barton JM, Olson MS: The specific binding of the platelet-activating factor (PAF) receptor antagonist WEB 2086 and benzodiazepine receptor antagonist flunitrazepam to rat hepatocytes. Life Sciences 58:81-6, 1995.
8. Svetlov, S.I. and Hanahan, D.J. Dual effect of propranolol on the human platelet activation by thrombin : potentiation of free intracellular Ca2+ mobilization and inhibition of phospholipase D activities.Adv. Exp. Med. Biol. 1997; 400A, 199-205
9. Svetlov SI, Howard KM, Miwa M, Flickinger B, Olson MS: Interaction of platelet-activating factor with rat hepatocytes in primary culture: effect on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. Arch Biochem Biophys 327:113-22, 1996.
10. Svetlov SI, Siafaka-Kapadai N, Hanahan DJ, Olson MS: Signaling responses to alkyl-lysophosphatidic acid: activation of phospholipases A2 and C and protein tyrosine phosphorylation in human platelets. Arch Biochem Biophys 336:59-68, 1996.
11. Svetlov SI, Liu H, Chao W, Olson MS: Regulation of platelet-activating factor (PAF) biosynthesis via CoA-independent transacylase in IC-21 peritoneal macrophages stimulated with lipopolysaccharide. Biochim Biophys Acta 1346:120-30, 1997.
12. Svetlov SI, Sturm E, Zimmerman-Kraynak T, Crawford AR, DeBuysere MS, Olson MS, Crawford JM. (1998) Bacterial Endotoxin up-regulates biliary secretion of PAF-Acetylhydrolase (PAF-AH) in rats. Hepatology1998; 28, 4 (Pt 2): 253A
13. Svetlov SI, Howard KM, Olson MS. Secretory PAF-acetylhydrolase(s) of the rat Hepatobiliary System: Characterization and Partial Purification. Am. J. Physiology, 1998, 274(5 Pt 1): G891-G900.
14. Serebruany, V.L., Gurbel, P.A., Murugesan, S.R., Lowry, D.R., Sturm, E., Svetlov, S.I. Depressed Plasma Platelet-Activating Factor Acetylhydrolase in Patients Presenting with Acute Myocardial Infarction. Cardiology, 1998; 90:127-13016.
15. Siafaka-Kapadai A, Svetlov S, Hanahan DJ, Javors MA Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists.Life Sci. 1998;63(20):1769-77.
16. Svetlov SI, Sturm E, Olson MS, Crawford JM. Hepatic regulation of PAF-acetylhydrolase (PAF-AH) and Lecithin:Cholesterol Acyltransferase (LCAT) in rats exposed to bacterial lipopolisaccharide. Hepatology, 1999;30:128-136.
17. Svetlov SI, Moskaleva ES, Pinelis VG, Daikhin Ye, Serebruany VL: Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome. Pediatric Nephrology, 1999, 13(3), 205 208.
18. Sturm E, Zimmerman TL, Crawford A, Svetlov SI, Sundaram P, Ferrara JLM, Karpen SJ, Crawford JM Endotoxin-stimulated macrophages decrease bile acid uptake in WIF-B cells,a rat hepatoma hybrid cell line. Hepatology, 2000; 31(1): 124-130.
19. Sautin YuY, Crawford JM, Svetlov SI. Enhancement of survival by LPA via Erk1/Erk2 and PI-3 kinase/Akt/ - dependent pathways in a murine hepatocyte cell line.
    Amer. J. Physiol. 2001; 281 : C2010-C2019
20. Svetlov SI, Sautin Y.Y. Crawford JM. Edg receptors and hepatic pathophysiology of LPA and S1P: Edg-ology of liver injury. Biochim. Biophys. Acta, 2002, 1582 : 251-256
21. Sautin Y.Y., Jorgensen M, Petersen B.E., Crawford J.M. and Svetlov S.I. Hepatic oval (stem) cell expression of EDG receptors for lysophosphatidic acid in mouse chronic liver injury. J. Hematotherapy & Stem Cell Res. 2002 , 11 (4) 643-650
22. Svetlov SI, Ignatova TN, Wang KKW, Hayes RL, Kukekov VG. Lysophosphatidic Acid Induces Clonal Generation of Mouse Neurospheres via Proliferation of Sca-1 and AC133 - Positive Neural Progenitors. Stem Cells & Development , 2004, 13 (6) : 685-693
23. Johnson EA, Svetlov SI, Pike BR, Tolentino PJ, Shaw J, Wang KKW, Hayes RL, Pineda JA. Cell Specific Up-regulation of Survivin After Experimental Traumatic Brain Injury in Rats. J of Neurotrauma, 2004, 21 (9): 1183-1195
24. Johnson EA, Svetlov SI, Wang KKW, Hayes RL, Pineda JA. Cell-specific DNA fragmentation may be attenuated via survivin-dependent mechanism following traumatic brain injury in rats. Exp. Brain Res. 2005, 167(1):17-26.
25. Stanislav I. Svetlov, Guangling Huang, Yiwen Xiang, Ronald L. Hayes, Andrew Ottens, Kevin K.W. Wang Identification and characterization of novel biomarkers of hepatic ischemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers, 2006 11(4): 355-369
26. Yiwen Xiang, Erik A. Johnson, Chun Zhang, Guangling Huang, Ronald L Hayes, Kevin K.W. Wang, Stanislav I Svetlov. Generation of aberrant forms of DFF40 concurrent with caspase-3 activation during acute and chronic liver injury in rats. Biochem. Biophys. Res. Commun. 2006, Nov 17;350(2):457-62.
27. Warren MW, Kobeissy FH, Liu MC, Svetlov SI, Hayes RL, Gold MS, Wang KK. Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injury. J Addict Dis. 2006;25(4):115-23.
    Svetlov, SI, Kobeissy,F, Gold, M. Performance enhancing non-prescription use of Ritalin: a comparison with amphetamines and cocaine. Journal of Addictive Diseases, 2007, 26(4) 1-6
28. Atkinson JP, Faure JM, Kirk DR, Svetlov SI, Wang KKW, Hayes RL. Generation and Analysis of Blast Waves from a Compressed Air-Driven Shock Tube. The American Institute of Aeronautics and Astronautics (AIAA) Journal, 2008 (in press)
29. Joseph P. Atkinson, Joel M. Faure, Niroshen P. Divitotawela, Daniel R. Kirk, Hector M. Gutierrez, Raymond Rautenstrauch, Stanislav I. Svetlov, Ronald L. Hayes, and Kevin K. W. Wang AN INNOVATIVE WAVE GENERATION DEVICE AND IMPROVED EXPERIMENTAL PROTOCOL FOR CONDUCTING BLAST INJURY RESEARCH, J of Neurotrauma, 2008 (submitted)
30. Svetlov SI, Oli, M, Gabrielli, A., Wobst, A, Hayes, RL, Wang, KKW. Argininosuccinate synthase: a novel serum biomarker of liver injury in patients after liver transplantation. Transplantation Proceedings, 2008 (in press).