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Victor Prima, PhD.
Victor Prima, PhD.Title: Research Scientist

Education :1983 PhD, Molecular Biology, Institute of Molecular Biology and Genetics in Kiev, Ukraine
1973 BS/MS, Molecular Biology and Biophysics, Moscow Institute of Physics and Technology, Moscow, Russia

 

    Selected publications:

  1. Zhong CH, Prima V, Liang X, Frye C, McGavran L, Meltesen L, Wei Q, Boomer T, Varella-Garcia M, Gump J, Hunger SP. (2008) E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia. Leukemia. 22:723-729.
  2. Prima V, Hunger SP. (2007) Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia. Leukemia. 21:2470-24755.
  3. Baudis M, Prima V, Han Y, Hunger SP. (2006) ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemias with t(17;19) and E2A-HLF expression. Pediatr Blood Cancer. 47:757-764.
  4. Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP. (2005) Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. Leukemia. 19:806-813.
  5. Prima V, Tennant M, Gorbatyuk OS, Muzyczka N, Scarpace PJ, Zolotukhin S. (2004) Differential modulation of energy balance by leptin, CNTF, and LIF gene delivery: microarray DNA-chip analysis of gene expression. Endocrinology. 145:2035-2045.
  6. Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace P, Zolotukhin S. (2003) Sustained rAAV-mediated peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. PNAS. 100:14217-14222.
  7. Wilsey J, Zolotukhin S, Prima V, Scarpace PJ. (2003) Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5): R1011-20.
  8. Wilsey J, Zolotukhin S, Prima V, Shek EW, Matheny MK, Scarpace PJ. (2002) Hypothalamic
    delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and
    physiological responses. Gene Ther. 9:1492-1499.
  9. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tumer N. (2002) Leptin- induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology. 143:3026-3035.
  10. Scarpace PJ, Matheny M, Zhang Y, Tumer N, Fraze CD, Shek EW, Hong B, Prima V, Zolotukhin S. (2002) Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacol. 42:548-561.
  11. Levine LH, Levine HG, Stryjewski EC, Prima V, Piastuch WC. (2001) Effect of spaceflight on isoflavonoid accumulation in etiolated soybean seedlings. J Gravit Physiol. 8:21-27.
  12. Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS. (2001) Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regulatory Peptides 99:69-77.
  13. Dhillon H, Ge Y-L, Minter RM, Prima V, Moldawer LL, Muzyczka N, Zolotukhin S, Kalra PS, Kalra SP. (2000) Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice: Relationship with body weight change. Regulatory Peptides 92: 97-105.
  14. Levine HG, Sharek JA, Johnson KM, Stryjewski EC, Prima VI, Martynenko OI, Piastuch WC. (2000) Growth protocols for etiolated soybeans germinated within BRIC-60 canisters under spaceflight conditions. Advances in Space Research 26: 311-314.
  15. Prima V, Martynenko E, Vagin Y. (1999) The influence of low radiation doses on the content of superoxide dismutase RNA in different tissues of mice. Biopolymers and Cell. (Kiev) 15, No.4:289-291.
  16. Prima VI, Glushakova LG. (1998) Radiation -induced peculiarities of cytochrome P4502E1 and oncogenes mRNA accumulation in different rat tissues. Biopolymers and Cell. (Kiev) 14, No.6:540-544.
  17. Prima VI, Melnik NA, Martynenko E.I., Bartysh GV, Tchaykovskaya TA, Obolenskaya MYu. (1997) The expression of genes of two glutationtransferase isoformes in placenta of inhabitants of radioactively polluted and clean regions of Ukraine. Biopolymers and Cell (Kiev) 13:1-4.
  18. Prima VI, Kvitnitskaya AV, Glushakova LG, Tarasenko PD, Stogniy AB, Senyuk OF, Platonov OM. (1995) The influence of 2'5'oligoadenylates on the expression of cellular protooncogene c-myc during Svec leukemia in rats. Cytology and Genetics (Kiev) 29: 8-13.
  19. Danko IM, Prima VI. (1995) Actinomycin D-induced oscillations of nucleic acids synthesis in leukemic cells P-388. Biopolymers and Cell (Kiev) 11:46-50.
  20. Pater LV, Chripunov VA, Kvitnitskaya AB, Prima VI, Obolenskaya MYu, Platonov OM. (1994) Protooncogenes' c-myc and c-fos expression during the first cell cycle in regenerating rat liver. Biopolymers and Cell (Kiev) 10:57-61.
  21. Prima VI, Martynenko EI, Pater LV, Vagin YuV. (1993) "Genome fingerprinting" reveals DNA reorganizations in regenerating liver. Biopolymers and Cell (Kiev) 9:52-54.
  22. Stepanyuk VV, Smirnova GF, Klyushnikova TM, Kanyuk NI, Panchenko LP, Nogina TM, Prima VI. (1992) A new species of the Acinetobacter genus - Acinetobacter thermotoleranticus SP-Nov. Microbiology 61:347-356.
  23. Danko IM, Prima VI. (1992) Replication of oncogene c-myc in Erlich ascitic cells. Biopolymers and Cell (Kiev) 4:56-58.
  24. Prima VI, Klochko TA, Obolenskaya MYu, Ivanov PL, Ryskov AP, Platonov OM. (1989) Synchronous changes of c-fos RNA and B2mRNA concentrations during prereplicative period in regenerating rat liver. Biopolymers and Cell (Kiev) 5: 83-86.
  25. Obolenskaya MYu, Prima VI, Kulikovskaya IA, Platonov OM. (1987) Nuclear RNA at early stages of liver regeneration. Biopolymers and Cell (Kiev). 3: 27-35.
  26. Danko IM, Prima VI, Kazmin SD, Pinchuk VG. (1986) Effect of monovalent cations on the ratio of RNA transcripts from DNA sequences with different repetition in leukemia P-388 cells. Biochemistry (Moscow) 51: 458-462.
  27. Obolenskaya MYu, Prima VI, Platonov OM. (1984) Hybridization of eukaryotic nucleic acids at the presence of high formamide concentrations. Studia biophysica (Berlin). 2: 103-110.
  28. Buchatskii LP, Kuznetsova MA, Prima VI. (1983) Isolation and study of the physicochemical properties of the DNA of the iridescent virus from the mosquito Aedes cantans. Vopr Virusol. (Moscow) 3:355-358.
  29. Prima VI, Lisitsa EG, Platonov OM. (1982) The peculiarities of transcription of nuclear genome at early stages of liver regeneration. Biochemistry (Moscow) 47: 145-152.
  30. Prima VI. (1981) Hybridization of RNA from regenerating rat liver with the excess of DNA in formamide solution. Biopolymer structure and genetic functions (Kiev) 44-46.
  31. Prima VI, Platonov OM, Gazaryan KG. (1980) Analysis of reassociation of rat DNA fractions. Biochemistry (Moscow) 45: 498-506.
  32. Strokovskaya LI, Skuratovskaya IN, Gudz-Gorban AP, Zherebtsova EN, Prima VI, Kok IP. (1979) Macromolecular structure of nuclear polyhedrosis virus genome. Archives of Virol. 59: 331-343.

 

 

 
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