Stephen F. Larner, Ph.D.
Title:
Center Operations Manager
Principal Scientist
Education :
University of Oregon, B.B.S.,International Business, 1973
Northwestern University, M.M., Accounting/Finance, 1975
Seattle Pacific University, B.S., Biol./Chem./Comp. Sci., 1996
Seattle Pacific University, M.A.T.,Secondary Ed. Teaching, 1996
University of Washington, M.S., Biological Sciences, 2000
University of Florida, Ph.D., Neuroscience, 2004

Professional Memberships

National Neurotrauma Society
Society for Neuroscience
New York Academy of Sciences
C.P.A. - American Institute of Certified Public Accountants

Selected peer-reviewed publications (in chronological order).

1.    Ghatan S, Larner S, Kinoshita Y, Patel L, Xia Z, Youle RJ, Morrison RS (2000). p38-mitogen activated protein kinase mediates Bax translocation and caspase induction in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150:335-347.

2.    Larner SF, Hayes RL, McKinsey DM, Pike BR, Wang KKW (2004). Increased expression and processing of caspase-12 after traumatic brain injury in rats. J. Neurochem. 88:78-90.

3.    Larner SF, McKinsey DM, Hayes RL, Wang KKW (2005). Caspase-7: increased expression and activation after traumatic brain injury in rats. J. Neurochem. 94:97-108.

4.    Morse MJS, Shaw G, Larner SF (2006). Concurrent RNA and protein extraction from the same experimental sample using a commercially available column-based RNA preparation kit. Biotechniques 40: 54-55.

5.    Zhiqun ZQ, Ottens AK, Larner SF, Kobeissy FH, Williams ML, Hayes RL, Wang KKW (2006). Direct Rho-associated kinase inhibition induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells. Cell. Mol. Biol. Lett. 11: 15-32.

6.    Larner SF, Hayes RL, Wang KKW (2006). Review: Unfolded protein response after neurotrauma. J. Neurotrauma 23: 807-829.

7.    Sadasivan S, Waghray A, Larner SF, Dunn, Jr. WA, Hayes RL, Wang KKW (2006). Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1. Apoptosis 11: 1573-1582.

8.    Zhang ZQ, Kammerdiner AR, Busygin SP, Ottens AK, Larner SF, Kobeissy FH, Pardalos PM, Hayes RL, Wang KKW (2006). Application of the data mining techniques to the systems biology of neuritogenesis. Optimization Methods and Software 22: 215-224.

9.    Liu MC, Akle V, Zheng W, Kitlen J, O’Steen B, Larner SF, Dave JR, Tortella FC, Hayes RL, Wang KKW (2006). Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury. J. Neurochem. 98:700-712.

10.  Warren MW, Zheng W, Kobeissy FH, Liu MC, Hayes RL, Gold MS, Larner SF, Wang KKW (2006). Calpain and caspase mediated proteolysis of αII-spectrin and tau in rat cerebrocortical neuron cultures after ecstasy or methamphetamine exposure. Intl. J. Neuropsychopharmcology 2: 1-11.

11.  Wang KKW, Larner SF, Robinson G, Hayes RL (2006). Neuroprotection targets after traumatic brain injury. Curr. Opin. Neurol. 19: 514-519.

12.  Kobeissy FH, O’Donoghue MB, Golden EC, Larner SF, Zhang ZQ, Gold MS (2007). Performance enhancement and adverse consequences of MDMA. J Addict Dis. 25(Suppl 1):47-59.

13.  Kobeissy FH, O’Donoghue MB, Golden EC, Larner SF, Zhang ZQ, Gold MS (2007). Ch. 4: Performance enhancement and adverse consequences of MDMA. Haworth Press, Inc., Binghamton, NY. Performance Enchancing Medications and Drugs of Abuse (Ed. Gold MS).

14.  Warren MW, Larner SF, Kobeissy FH, Brezing CA, Jeung JA, Hayes RL, Gold MS, Wang KKW (2007). Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.  Acta Neuropathologica (Berl) 114: 277-286.

In press or in preparation

15.  Larner SF, Wang KKW, Hayes RL (2007). Ch. 5: Proteolytic Mechanisms of Cell Death in the Central Nervous System, Vol. 24: Brain and Spinal Cord Trauma, Handbook of Neurochemistry (Ed.-in-Chief: Lajtha A; Vol. Ed. Banik N) (In Press).

16.  Qui K, O’Donoghue MB, Hermel E, Ellerby LM, Larner SF, Wang KKW (2007). Overexpression of functionally active calpain-5 in HEK293 cells is associated with increased vulnerability to calcium induced necrosis. PLoS. (Submitted).

17.  Sadasivan S, Larner SF, Kobeissy F, Hayes RL, Wang KKW (2007). Acute NMDA toxicity in rat cerebellar granule neurons is accompanied by autophagy and 3-methyladenine-sensitive late onset autophagic cell death. (In preparation).